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শুক্রবার, ৩১ মে, ২০১৩
Lenovo's dual-SIM S820 unveiled, joins the Chinese league of feminine phones
Following the likes of the Oppo Ulike 2 and the MeituKiss, Lenovo's decided to join the fun with yet another phone targeted at Chinese female users. Dubbed the S820, this Android 4.2 device appears to be prettier -- with a hint of HTC's One X on both sides -- yet also more gender neutral than the older S720, but Lenovo's marketing team has been working hard to emphasize the phone's vivid redness, soft curves and velvet finish to back its case. Even the launch event yesterday featured bikini-clad models holding the new product, though that might have backfired a little.
Unlike the two aforementioned devices from the competition, the S820 only comes with a 2-megapixel front-facing camera instead of a 5- or 8-megapixel version, but it does have a 13-megapixel imager on the back. You'll also find a 4.7-inch, 720p gapless IPS display on top of a 1.2GHz quad-core MT6589 SoC with 1GB RAM and 4GB internal storage. Removing the flexible back cover reveals a removable 2,000mAh battery, dual SIM slots (WCDMA 2100 and GSM 900/1800/1900) and microSD expansion of up to 32GB. Not bad for ¥1,999 or about $330, and it's already available for pre-order from now until June 2nd. For now, you can check out a hands-on video of the S820 after the break, courtesy of a Dongguan-based trading company.
Filed under: Cellphones, Mobile, Lenovo
Via: CNMO
Source: Lenovo
Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/1pwcj1NzVuE/
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US economy grew 2.4 percent in first quarter
In this March 1, 2013 photo, a crane removes a container from a ship at the Port of Baltimore's Seagirt Marine Terminal in Baltimore. The government reports on the U.S. trade deficit for March, Thursday, May 2, 2013. (AP Photo/Patrick Semansky)
In this March 1, 2013 photo, a crane removes a container from a ship at the Port of Baltimore's Seagirt Marine Terminal in Baltimore. The government reports on the U.S. trade deficit for March, Thursday, May 2, 2013. (AP Photo/Patrick Semansky)
WASHINGTON (AP) ? The U.S. economy grew at a modest 2.4 percent annual rate from January through March, slightly slower than initially estimated. Consumer spending was stronger than first thought, but businesses restocked more slowly and state and local government spending cuts were deeper.
The Commerce Department said Thursday that economic growth in the first quarter was only marginally below the 2.5 percent rate estimated last month. That's still much faster than the 0.4 percent growth during the October-December quarter.
Economists believe growth is slowing to around a 2 percent rate in the April-June quarter, as the economy adjusts to federal spending cuts, higher taxes and further global weakness. Still, many say the decline may not be as severe as once thought. That's because solid hiring, surging home prices and record stock gains should keep consumers spending.
Jennifer Lee, senior economist at BMO Capital Markets, said that the small revision to first-quarter growth supported her view that the economy will grow a moderate 2.2 percent for the year, the same as last year.
Still, Lee expects growth to improve to 3.2 percent in 2014, as the job market accelerates and consumers grow more confident in the economy.
Consumer spending accounts for 70 percent of economic activity as measured by the gross domestic product. GDP is the economy's total output of goods and services, from haircuts and computers to trucks and aircraft carriers.
The government's second look at first-quarter growth showed that consumer spending roared ahead at a 3.4 percent rate. That's the fastest spending growth in more than two years and even stronger than the 3.2 percent rate estimated last month.
Healthy consumer spending shows many Americans are shrugging off an increase this year in Social Security taxes that has reduced most paychecks.
And more consumer demand could also prompt businesses to restock at a faster rate later this year. Business inventories grew in the first quarter but at a slightly slower pace than first estimated. That was a key reason for the small revision.
A big reason that consumers have been able to withstand the higher taxes is the job market has improved. Employers have added an average of 208,000 jobs a month since November. That's well above the monthly average of 138,000 during the previous six months.
Surging stock prices and steady home-price increases have also allowed Americans to regain the $16 trillion in wealth they lost to the Great Recession. Higher wealth tends to embolden people to spend more. Some economists have said the increase in home prices alone could boost consumer spending enough to offset a Social Security tax increase.
The weakest area of the economy continues to be government spending, which fell for the 10th time in the last 11 quarters. The 4.9 percent rate of decline was even larger than first estimated, reflecting further drops in defense spending and weaker activity at the state and local level.
And with the federal government furloughing workers and trimming other spending to meet the mandates of the sequester, government activity will be a drag on growth for the rest of the year.
The housing recovery continued to add to growth at the start of the year. Home construction, one of the economy's top performers, grew at an annual rate of 12.1 percent in the first quarter, its third consecutive quarter of double-digit growth.
Businesses, however, reduced the pace of their investment in equipment and computer software. That slowed to a growth rate of 4.6 percent in the first quarter, down from growth of 11.8 percent in the fourth quarter.
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বৃহস্পতিবার, ৩০ মে, ২০১৩
91% Frances Ha
All Critics (74) | Top Critics (31) | Fresh (67) | Rotten (7)
The dialogue and editing are zippy and generally charming, combining with the tart observations of 20-something culture to create a nice frisson.
A black-and-white salute to the French New Wave (the score is borrowed from Georges Delerue, composer of many a Truffaut and Godard film) that manages to be very much of this moment ...
The movie's a love letter to an actress and her character, but by the end you may feel like an intervention is more in order.
The obvious love of New York City echoes Woody Allen at his best. But "Frances Ha" is very much its own film, a story of life and love and messy rooms.
Baumbach ... makes the film a celebration of Gerwig's coltish, goofball appeal.
Late-blooming 20-somethings have never been so perfectly captured -- and Gerwig has never been more appealing -- than in this funny, tender, life-affirming movie.
One of the most appealing films of the year to date -- and it may well end up being the most appealing indie release of the entire year
This is a tough one, but I must recommend it, if you are at all inclined to witness creativity at its unconventional best.
"Frances Ha"? More like Frances Bah!
Gerwig dances the Millennial Limbo
...caters to the Gerwig persona while also sanding off the edges of Baumbach's usual bitterness.
"Frances Ha" is about the inevitability of adulthood; it can be postponed, but it can't be avoided.
[a] fresh-faced and spirited black and white comedy...
If Frances has a chance, there's hope for us all.
The near-incomparable Greta Gerwig gives Frances a fire, an exuberance, and a three-dimensional uniqueness that ensures the viewer never sways from her side.
It gives you two choices: find it delightful or don't: there is no unique, self-guided option. As frustrating as that conundrum may be, it's still hard not to take option one.
Without Gerwig, this story of a hopeful young woman making her way in New York would have been just like all the rest. Instead, it's a work of art.
But there's just something so relentlessly likable about put-upon, impoverished Frances (Greta Gerwig) that it almost doesn't matter that her New York is just one big Williamsburg.
Improbable yet engaging, this arrested development serio-comedy should be particularly endearing to those who can't quite get their lives together.
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Source: http://www.rottentomatoes.com/m/frances_ha_2013/
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In China, US official promotes military ties
BEIJING (AP) -- U.S. National Security Adviser Tom Donilon pushed Tuesday for stronger military relations with China, on the final day of a visit to Beijing to set the stage for a summit next month between President Barack Obama and China's Xi Jinping.
Nontraditional military activities such as peacekeeping, disaster relief and anti-piracy operations offer opportunities to boost cooperation and "contribute to greater mutual confidence and understanding," Donilon told Gen. Fan Changlong, a vice chairman of the commission overseeing China's armed forces.
A "healthy, stable, and reliable military-to-military relationship" is an essential part of overall China-U.S. ties, Donilon said at the start of the meeting at China's hulking Defense Ministry building in central Beijing.
Donilon met with a range of Chinese officials over two days to hammer out plans for the June 7-8 summit, the first face-to-face meeting between the presidents since Obama's re-election and Xi's promotion to Communist Party chief last November.
Their informal summit at the private Sunnylands estate of the late publishing tycoon Walter Annenberg in southern California will come months before the two leaders had been originally scheduled to meet, underscoring concerns that the U.S-China relationship was drifting.
Xi told Donilon on Monday that relations were at a critical juncture, and that the sides must now "build on past successes and open up new dimensions for the future."
Building trust between their militaries is one of the main challenges the sides face in seeking to stop a drift in relations, troubled by issues from trade disputes to allegations of Chinese cyberspying.
A White House statement issued after Tuesday's meeting emphasized the need to cooperate further on North Korea, cyber-security, climate change and stability in Asia. It called the upcoming summit a "unique and important opportunity" to discuss U.S.-China relations and regional and global challenges facing both countries.
Although Washington and Beijing have talked about boosting military cooperation for more than a decade, distrust runs high and disagreements over Taiwan, North Korea and China's assertive claims to disputed territories in the East and South China seas remain potential flashpoints.
The U.S. has repeatedly questioned the purpose of China's heavy military buildup over the past two decades, while Beijing is deeply suspicious of Washington's new focus on military alliances in Asia and plans to redeploy more weaponry and troops to the Asia-Pacific region.
Steps to increase benign interactions between their militaries have been modest so far, including joint anti-piracy drills in the Gulf of Aden and a classroom natural disaster response simulation. The U.S. has also invited China to take part in large U.S.-led multinational naval exercises, though China has not said if it would participate.
Apart from purely military issues, distrust has deepened as the U.S. feels its world leadership challenged and China, its power growing, demands greater deference to its interests and a larger say over global rule-setting. Chinese officials and state media regularly say Washington is thwarting China's rise by hemming Beijing in through its Asian alliances and discouraging Chinese investment in the U.S. on grounds of national security.
Source: http://hosted.ap.org/dynamic/stories/A/AS_CHINA_US?SITE=INELK&SECTION=HOME&TEMPLATE=DEFAULT
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Sonos app updates foster Spotify integration, easier playlist building
If you're peddling wireless speaker systems that offer internet streaming support, it's only natural to want to get cozy with Spotify. Sonos' latest update for its iOS and Android Controller apps does just that, and you can now log-in to the streaming service using your Facebook account. What's more, version 4.1 makes handling mixtapes easier, as you can access, edit or build new Spotify playlists from within the app. Revising your Sonos playlists, or creating new ones altogether, has also been tweaked so you no longer need to involve the 'now playing' queue. Lastly, the alarm function can now be set to wake you with the sounds of your preferred subscription service, taking you straight from dreaming to streaming.
Filed under: Cellphones, Home Entertainment, Tablets, Software, HD
Source: iTunes store (iPhone / iPod), (iPad), Google Play, Sonos
Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/UvjyPjnV6wA/
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Cicadas now emerging on Staten Island
Cicadas of the Brood II population are now making their debut in New York City, for the first time in 17 years.
After a dark 17-year juvenile period underground, Brood II cicadas having been emerging along the East Coast.
Courtesy of the National Pest Management Association / Tom Meyers
EnlargeThe 17-year-old sex-crazed cicadas of Brood II have started to stir in Staten Island.
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Historically, large numbers of these periodical cicadas have spent their short but dramatic adulthoods in the borough, but they might be harder to spot elsewhere in New York City.
The noisy creatures started emerging by the hundreds last week in certain parts of Staten Island, said Edward Johnson, director of science at the Staten Island Museum. But the insects are not likely to come out in droves in Brooklyn, Queens, the Bronx and Manhattan, Johnson added.
"They don't fly very far as adults, and so are unlikely to colonize other boroughs from Staten Island," he said. [Ewww! 6 Crazy Facts About Cicadas]
Brood II is one of the distinct cicada populations that only matures every 13 or 17 years. Known as?periodical cicadas, they belong to the genus?Magicicada, and they can be found only in the eastern half of North America. Brood II's range extends from Georgia to Connecticut and it began its emergence earlier this month.
Their loud mating calls and carpet of corpses may come as a nuisance to some, but each emergence is exciting for entomologists studying the mysterious, long-lived insects ? they spend most of their lives in an immature stage. The cicadas coming out of the ground now were born in 1996, meaning they're the first Brood II generation to be greeted by Twitter and Flickr, which make it possible for people to socially share their pictures of the insects.?Radiolab's Cicada Tracker?and?Magicicada?as well allow citizen scientists to report their sightings in real time.
Mapping where these 17-year cicadas emerge could offer new insights on land use, climate change and the bugs themselves. The cicadas' long subterranean youth, which may be the longest of any known insect, means it's difficult for scientists to study their life cycle.
Geographically, the 17-year brood populations fit together like puzzle pieces. Brood II is almost like the keystone, since its range borders that of many other broods, University of Connecticut cicada expert John Cooley said earlier this month. Scientists think they might be able to learn about why different broods evolved by studying their boundaries.
For Johnson, the emergence will give him a chance to show off the Staten Island Museum's collection of?cicadas, the second largest in the world. He said he has dim memories of the Brood II emergences on Staten Island in 1962 and 1979, but better recollections from last time, in 1996.
From that year, Johnson recalls "lots of cicada song and activity in the woodlands, lots of media attention, and my youngest son was born three months before the emergence, so he is a 'cicada baby,' and gets to measure his life in cicada years."
Source: http://rss.csmonitor.com/~r/feeds/science/~3/0jb0PlJjGjQ/Cicadas-now-emerging-on-Staten-Island
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Despite safety and other concerns, nuclear power saves lives, greenhouse gas emissions
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Public release date: 29-May-2013[ | E-mail |
Share ] Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society
Global use of nuclear power has prevented about 1.84 million air pollution-related deaths and release of 64 billion tons of greenhouse gases that would have resulted from burning coal and other fossil fuels, a new study concludes. It appears in the ACS journal Environmental Science & Technology.
Pushker A. Kharecha and James E. Hansen state that nuclear power has the potential to help control both global climate change and illness and death associated with air pollution. That potential exists, they say, despite serious questions about safety, disposal of radioactive waste and diversion of nuclear material for weapons. Concerned that the Fukushima accident in Japan could overshadow the benefits of nuclear energy, they performed an analysis of nuclear power's benefits in reducing carbon dioxide emissions and air pollution deaths.
The study concluded that nuclear power already has had a major beneficial impact, based upon calculations of prevented mortality and greenhouse gas emissions for the period 1971-2009. Nuclear power could prevent from 420,000 to 7 million additional deaths by mid-century, and prevent emission of 80-240 billion tons of the greenhouse gases linked to global warming, the study found. "By contrast, we assess that large-scale expansion of unconstrained natural gas use would not mitigate the climate problem and would cause far more deaths than the expansion of nuclear power," it notes. If the role of nuclear power declines significantly in the next 20-30 years, Kharecha added, the International Energy Agency predicts that achieving the major reductions in greenhouse gas emissions that are required to mitigate climate change would require "heroic achievements" in the use of emerging low-carbon technologies, which have yet to be proven.
###
The authors acknowledge funding from the Lenfest Foundation and the Columbia University-NASA Cooperative Agreement.
The American Chemical Society is a nonprofit organization chartered by the U.S. Congress. With more than 163,000 members, ACS is the world's largest scientific society and a global leader in providing access to chemistry-related research through its multiple databases, peer-reviewed journals and scientific conferences. Its main offices are in Washington, D.C., and Columbus, Ohio.
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Public release date: 29-May-2013[ | E-mail |
Share ] Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society
Global use of nuclear power has prevented about 1.84 million air pollution-related deaths and release of 64 billion tons of greenhouse gases that would have resulted from burning coal and other fossil fuels, a new study concludes. It appears in the ACS journal Environmental Science & Technology.
Pushker A. Kharecha and James E. Hansen state that nuclear power has the potential to help control both global climate change and illness and death associated with air pollution. That potential exists, they say, despite serious questions about safety, disposal of radioactive waste and diversion of nuclear material for weapons. Concerned that the Fukushima accident in Japan could overshadow the benefits of nuclear energy, they performed an analysis of nuclear power's benefits in reducing carbon dioxide emissions and air pollution deaths.
The study concluded that nuclear power already has had a major beneficial impact, based upon calculations of prevented mortality and greenhouse gas emissions for the period 1971-2009. Nuclear power could prevent from 420,000 to 7 million additional deaths by mid-century, and prevent emission of 80-240 billion tons of the greenhouse gases linked to global warming, the study found. "By contrast, we assess that large-scale expansion of unconstrained natural gas use would not mitigate the climate problem and would cause far more deaths than the expansion of nuclear power," it notes. If the role of nuclear power declines significantly in the next 20-30 years, Kharecha added, the International Energy Agency predicts that achieving the major reductions in greenhouse gas emissions that are required to mitigate climate change would require "heroic achievements" in the use of emerging low-carbon technologies, which have yet to be proven.
###
The authors acknowledge funding from the Lenfest Foundation and the Columbia University-NASA Cooperative Agreement.
The American Chemical Society is a nonprofit organization chartered by the U.S. Congress. With more than 163,000 members, ACS is the world's largest scientific society and a global leader in providing access to chemistry-related research through its multiple databases, peer-reviewed journals and scientific conferences. Its main offices are in Washington, D.C., and Columbus, Ohio.
To automatically receive news releases from the American Chemical Society, contact newsroom@acs.org.
Follow Us: Twitter Facebook
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2013-05/acs-dsa052913.php
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Can backpackers solve Middle East's tourism woes?
An Israeli tourism entrepreneur believes tourism does far more than bring in cash, and has built a top-rated hostel to bring tourists in, particularly the young backpacker crowd.
Maoz Inon recently spoke about his vision for sustainable tourism at the first international Jerusalem symposium on green and accessible pilgrimage.
Christa Case Bryant/TCSM
EnlargeWhere others give PowerPoint presentations about wooing more souls to a storied land, he wears a faded ?staff? T-shirt with a button that says, ?In fun we trust.? He actively courts travelers who have visited countries at war with Israel, including Syria, Lebanon, Iran, and Iraq, and aims to boost tourism to the whole Middle East one backpacker at a time.
Skip to next paragraph Christa Case BryantJerusalem bureau chief
Christa Case Bryant is The Christian Science Monitor's Jerusalem bureau chief, providing coverage on Israel and the Palestinian territories as well as regional issues.
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Meet Maoz Inon, Israel?s maverick tourism entrepreneur, whose latest venture was just recognized as one of the top 10 large hostels worldwide.
?I believe tourism is a great tool also to create political change, to create a very big impact,? he says. ?Backpackers are the first adopters, so we must target them.?
Mr. Inon?s foray into shoestring travel in Israel began eight years ago in the Old City of Nazareth, one of Israel?s poorest neighborhoods, which was riddled with drugs and not exactly a prime tourist destination ? even for the adventurous. But after he and his wife decided to leave their ?yuppie lives? in Tel Aviv and spent months backpacking along California?s Pacific Crest Trail and later Patagonia at the tip of South America, they had returned home with a mission.
?I believe the No. 1 beneficiary should be the local community,? he says, having witnessed firsthand the transformative effect of responsible tourism.
He found a gem of an old mansion in Nazareth?s warren of stone alleyways, and turned its soaring arches and tiled ceilings into the Fauzi Azar Inn, named after the Arab family that occupied it until the 1980s. By creating a free map and daily tours of the Old City, as well as co-founding the Jesus Trail that runs from Fauzi?s steps to the shores of the Galilee, he helped create such a demand that six more guesthouses have since opened up in the Old City.
With visitors from places as cosmopolitan as London and far-flung as Mongolia, he says his inn and its clientele are gradually turning perceptions of Nazareth inside out.
?It is raising the self-esteem of the community and creating a psychological change in their mind,? says Inon, who partners with local businesses ??including other guesthouses ??and organizes home-cooked dinners in a local family?s home for 80 shekels ($22) a head.
?Sustainable business is not about recycling or solar power,? he says. ?It?s about being a profitable business.
And he seems to have a knack for spotting such opportunities. The Abraham Hostel, which he opened in 2010 with several other Israeli backpackers, became a top-ranked Israeli hostel before renovations on all 72 rooms?were even completed. In February, the annual Hoscars competition named it the 8th?best large hostel in the world ? the only Israeli hostel to get a mention in any of the four categories.
?I believe backpackers are the foundation of sustainable tourism,? he says. ?I see them as the planktons in the ocean that we feed on.?
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বুধবার, ২৯ মে, ২০১৩
Title of new Bridget Jones novel revealed
LONDON (AP) ? Everyone's favorite literary singleton will return in a new novel entitled "Bridget Jones: Mad About the Boy."
Publishers disclosed the title of Helen Fielding's forthcoming book on Tuesday.
It continues the comic saga of diary-writing Bridget's romantic and professional adventures.
The character, introduced to readers in two 1990s' novels, now must cope with an age of text messaging and social media.
Fielding said Bridget is older now and her "life has moved on. But, the question is, just how much?"
The previous books, "Bridget Jones's Diary" and "Bridget Jones: The Edge of Reason," sold 15 million copies between them and were adapted into movies starring Renee Zellweger.
The new book will be published Oct. 10 in Britain by Jonathan Cape, and Oct. 15 in the U.S. by Alfred A. Knopf.
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Fast-Spinning Magnetic Star Has Strange Glitch
One of the strongest magnets in the universe, a magnetar, is unexpectedly capable of a strange new kind of glitch ? a mysterious, unexplained drop in speed, researchers say.
Unraveling what briefly put the brakes on this powerhouse's spin could help shed light on states of matter that scientists currently are not able to recreate in labs, scientists added.
Magnetars are a type of neutron star, which is the core of a massive star that devoured all its fuel, collapsed under its own weight and then exploded as a supernova. Magnetars are also often thought of as the most powerful magnets in the cosmos, with magnetic fields up to approximately 5,000 trillion times that of the Earth's. Astronomers have discovered less than two dozen magnetars so far. [The Top 10 Star Mysteries Ever]
"Magnetars are really spectacular and mysterious objects," study co-author Victoria Kaspi, an astrophysicist at McGill University in Montreal and leader of the Swift magnetar monitoring program, told SPACE.com. "They can unleash extraordinary explosions and have the highest magnetic fields known in the universe, but they're relatively tiny, just the size of a city or so. How do they combine all that? We really want to understand them better."
The explosions that give birth to neutron stars, including magnetars, crush them into some of the densest objects known, second only to black holes ? a neutron star often packs as much mass as a half-million Earths within a diameter of only 12 miles (20 kilometers), and a teaspoonful of neutron star matter would weigh about 1 billion tons on Earth, approximately twice the combined weight of all the cars in the United States. This extraordinary mass gives a neutron star a powerful gravitational field as well ? a projectile would need to fly at about half the speed of light to escape from its surface.
Neutron stars can also spin as fast as the blades of a kitchen blender, up to 43,000 revolutions per minute. Past studies revealed hundreds of neutron stars can undergo changes in speed dubbed "glitches," in which the stars suddenly whirled faster.
Now for the first time, scientists have discovered that neutron stars can abruptly slow down as well, a surprising irregularity currently unexplained by existing models of neutron stars.
"We've dubbed this event an 'anti-glitch' because it affected this star in exactly the opposite manner of every other clearly identified glitch seen in neutron stars," said study co-author Neil Gehrels, the lead researcher on the Swift mission at NASA's Goddard Space Flight Center.
Scientists focused on the magnetar 1E 2259+586, located about 10,000 light-years from Earth in the constellation of Cassiopeia, using NASA's Swift observatory to watch it from July 2011 to mid-April 2012. Ordinarily, the magnetar completed a revolution every seven seconds, but the researchers discovered it had later slowed by 2.2 millionths of a second.
"I looked at the data and was shocked ? the neutron star had suddenly slowed down," said study lead author Rob Archibald at McGill University. "These stars are not supposed to behave this way." [Star Quiz: Take the Stellar Challenge]
The extreme forces that matter in neutron stars experience theoretically gives rise to a host of bizarre, exotic phenomena that might explain regular glitches. For instance, researchers suspect the interior of a neutron star possesses, among other curiosities, a kind of frictionless state of matter known as a neutron superfluid. This superfluid is thought to make a neutron star's core spin faster than its crust, occasionally giving the crust bursts of speed that astronomers saw as glitches.
Now scientists have to explain how anti-glitches might come to exist.
"There was a huge outburst of X-rays from the magnetar a week before the anti-glitch was discovered, which does seem to suggest some process in its interior is responsible," Kaspi said.
One possibility is that a neutron star may have pockets of superfluids under its crust that each move at different speeds. These pockets could end up revolving more slowly around the neutron star's core than its crust, ultimately braking its spin in an anti-glitch. Another possibility is that internal vortexes of neutron superfluid that normally help drive the neutron star crust's movements could get driven inward by powerful concentrations of magnetic force emanating from the neutron star's core.
Learning more about what causes anti-glitches might shed light on longstanding mysteries about matter under extremes. For example, matter in neutron stars can get squeezed to densities up to more than 10 times greater than in the atomic nucleus, far beyond what current theories of matter can describe.
"Magnetars are the universe's strongest magnets and are some of the best laboratories we have for understanding pure physics," said study coauthor astronomer Jamie Kennea, an astronomer at Pennsylvania State University. "The extreme conditions on these stars could never be replicated in any laboratory here on Earth."
Now that one anti-glitch has been discovered, further analysis of past findings might turn up smaller, less conclusive examples, Kaspi said. Future research, such as that conducted bythe NICER (Neutron star Interior Composition ExploreR) X-ray telescope recently approved to go on the International Space Station, might help discover more anti-glitches, Kaspi said.
In addition, some existing models of neutron star glitches cannot explain some of the behavior astronomers have seen from them. A better understanding of anti-glitches might help solve these puzzles as well, Kaspi said.
The scientists detailed their findings in the May 30 issue of the journal Nature.
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Copyright 2013 SPACE.com, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.Source: http://news.yahoo.com/fast-spinning-magnetic-star-strange-glitch-171412599.html
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Researchers identify novel class of drugs for prostate cancers
Public release date: 28-May-2013[ | E-mail |
Share ] Contact: Jan Jarvis
janice.jarvis@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
DALLAS May 28, 2013 A new study on prostate cancer describes a novel class of drugs developed by UT Southwestern Medical Center researchers that interrupts critical signaling needed for prostate cancer cells to grow.
In men with advanced prostate cancer, growth of cancer cells depends on androgen receptor signaling, which is driven by androgens, such as testosterone. To thwart tumor growth, most patients with advanced prostate cancer receive drugs that block the production of androgen or block the receptor where the androgen binds. Unfortunately, such treatments invariably fail and patients die of prostate cancer with their androgen receptor signaling still active and still promoting tumor growth.
In the new study, available online at Nature Communications, a team of researchers led by Dr. Ganesh Raj, associate professor of urology at UT Southwestern, found that they could disrupt androgen receptor signaling using a novel class of drugs called peptidomimetics. This therapeutic agent consists of an engineered small protein-like chain designed to mimic peptides that are critical for androgen receptor function. The peptidomimetic agents block the activity of the androgen receptor even in the presence of androgen by attacking the protein in a different spot from where the androgen binds.
"We are hopeful that this novel class of drugs will shut down androgen receptor signaling and lead to added options and increased longevity for men with advanced prostate cancer," said Dr. Raj, the senior author of the study.
Dr. Raj compared the action that takes place to a lock and key mechanism. In prostate cancer, the androgen receptor (lock) is activated by the androgen (key) resulting in a signal that causes prostate cancer proliferation. In advanced prostate cancer, despite drugs targeting either the lock (androgen receptor) or the key (androgen production), there can be aberrant keys that open the lock or mutated locks that are always open, resulting in cancer cell proliferation. Instead of trying to block the lock or the key, peptidomimetics uncouple the lock and key mechanism from the proliferation signal. Thus, even with the androgen receptor activated, the prostate cancer cells do not receive the signal to proliferate and do not grow.
The researchers tested their drug in mouse and human tissue models. The novel drug proved non-toxic and prevented androgen receptor signaling in cancer cells. The response is highly promising and suggests that peptidomimetic targeting of prostate cancer may be a viable therapeutic approach for men with advanced disease.
Further testing is needed before a drug could move to Phase 1 clinical trials that involve human participants.
"Most drugs now available to treat advanced prostate cancer improve survival rates by three or four months," Dr. Raj said. "Our new agents may offer hope for men who fail with the current drugs."
These findings represent the development of a first-in-class agent targeting critical interactions between proteins. Other cellular and disease processes eventually could also be targeted with peptidomimetics, the scientists said.
###
Other UT Southwestern researchers involved in the study are Preethi Ravindranathan, a technician in Dr. Raj's laboratory, Dr. Jer-Tsong Hsieh, professor of urology, and Dr. Jung-Mo Ahn, visiting associate professor of urology. Researchers from University of Texas at Dallas; the First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Urology Institute of Xi'an Jiaotong University; Dame Roma Mitchell Cancer Research Laboratories and Adelaide Prostate Cancer, Research Center, University of Adelaide and Hanson Institute also contributed to the research.
The Prostate Cancer Foundation, the Dorothy and James Cleo Thompson Foundation, and the Robert A. Welch Foundation funded the research.
Visit the Department of Urology or the Harold C. Simmons Cancer Center to learn more about treatment for prostate cancer at UT Southwestern, including highly individualized treatments at the region's only National Cancer Institute-designated center.
About UT Southwestern Medical Center
UT Southwestern, one of the premier academic medical centers in the nation, integrates pioneering biomedical research with exceptional clinical care and education. The institution's faculty has many distinguished members, including five who have been awarded Nobel Prizes since 1985. Numbering more than 2,700, the faculty is responsible for groundbreaking medical advances and is committed to translating science-driven research quickly to new clinical treatments. UT Southwestern physicians provide medical care in 40 specialties to nearly 90,000 hospitalized patients and oversee more than 1.9 million outpatient visits a year.
This news release is available on online at http://www.utsouthwestern.edu/home/news/index.html
To automatically receive news releases from UT Southwestern via email, subscribe at http://www.utsouthwestern.edu/receivenews
[ | E-mail | Share ] ?
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Public release date: 28-May-2013[ | E-mail |
Share ] Contact: Jan Jarvis
janice.jarvis@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
DALLAS May 28, 2013 A new study on prostate cancer describes a novel class of drugs developed by UT Southwestern Medical Center researchers that interrupts critical signaling needed for prostate cancer cells to grow.
In men with advanced prostate cancer, growth of cancer cells depends on androgen receptor signaling, which is driven by androgens, such as testosterone. To thwart tumor growth, most patients with advanced prostate cancer receive drugs that block the production of androgen or block the receptor where the androgen binds. Unfortunately, such treatments invariably fail and patients die of prostate cancer with their androgen receptor signaling still active and still promoting tumor growth.
In the new study, available online at Nature Communications, a team of researchers led by Dr. Ganesh Raj, associate professor of urology at UT Southwestern, found that they could disrupt androgen receptor signaling using a novel class of drugs called peptidomimetics. This therapeutic agent consists of an engineered small protein-like chain designed to mimic peptides that are critical for androgen receptor function. The peptidomimetic agents block the activity of the androgen receptor even in the presence of androgen by attacking the protein in a different spot from where the androgen binds.
"We are hopeful that this novel class of drugs will shut down androgen receptor signaling and lead to added options and increased longevity for men with advanced prostate cancer," said Dr. Raj, the senior author of the study.
Dr. Raj compared the action that takes place to a lock and key mechanism. In prostate cancer, the androgen receptor (lock) is activated by the androgen (key) resulting in a signal that causes prostate cancer proliferation. In advanced prostate cancer, despite drugs targeting either the lock (androgen receptor) or the key (androgen production), there can be aberrant keys that open the lock or mutated locks that are always open, resulting in cancer cell proliferation. Instead of trying to block the lock or the key, peptidomimetics uncouple the lock and key mechanism from the proliferation signal. Thus, even with the androgen receptor activated, the prostate cancer cells do not receive the signal to proliferate and do not grow.
The researchers tested their drug in mouse and human tissue models. The novel drug proved non-toxic and prevented androgen receptor signaling in cancer cells. The response is highly promising and suggests that peptidomimetic targeting of prostate cancer may be a viable therapeutic approach for men with advanced disease.
Further testing is needed before a drug could move to Phase 1 clinical trials that involve human participants.
"Most drugs now available to treat advanced prostate cancer improve survival rates by three or four months," Dr. Raj said. "Our new agents may offer hope for men who fail with the current drugs."
These findings represent the development of a first-in-class agent targeting critical interactions between proteins. Other cellular and disease processes eventually could also be targeted with peptidomimetics, the scientists said.
###
Other UT Southwestern researchers involved in the study are Preethi Ravindranathan, a technician in Dr. Raj's laboratory, Dr. Jer-Tsong Hsieh, professor of urology, and Dr. Jung-Mo Ahn, visiting associate professor of urology. Researchers from University of Texas at Dallas; the First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Urology Institute of Xi'an Jiaotong University; Dame Roma Mitchell Cancer Research Laboratories and Adelaide Prostate Cancer, Research Center, University of Adelaide and Hanson Institute also contributed to the research.
The Prostate Cancer Foundation, the Dorothy and James Cleo Thompson Foundation, and the Robert A. Welch Foundation funded the research.
Visit the Department of Urology or the Harold C. Simmons Cancer Center to learn more about treatment for prostate cancer at UT Southwestern, including highly individualized treatments at the region's only National Cancer Institute-designated center.
About UT Southwestern Medical Center
UT Southwestern, one of the premier academic medical centers in the nation, integrates pioneering biomedical research with exceptional clinical care and education. The institution's faculty has many distinguished members, including five who have been awarded Nobel Prizes since 1985. Numbering more than 2,700, the faculty is responsible for groundbreaking medical advances and is committed to translating science-driven research quickly to new clinical treatments. UT Southwestern physicians provide medical care in 40 specialties to nearly 90,000 hospitalized patients and oversee more than 1.9 million outpatient visits a year.
This news release is available on online at http://www.utsouthwestern.edu/home/news/index.html
To automatically receive news releases from UT Southwestern via email, subscribe at http://www.utsouthwestern.edu/receivenews
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2013-05/usmc-rin052813.php
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Blog Monetization Service Skyscraper Comes Out Of Closed Beta, Adds VigLink Integration & WordPress Plugin
Skyscraper launched last year as a pretty straightforward blog advertising service with a focus on helping bloggers make money through direct ad sales. That's still a main part of its business, and it is currently serving up more than 1.5 million ads every day, but as its co-founder Paul Burger told me last week, the company's focus is slowly shifting to becoming a full-service blog monetization service that "covers all bases." Until today, Skyscraper was only available as a closed beta, but it's now open for all.Source: http://feedproxy.google.com/~r/Techcrunch/~3/gF5pt40t5Fk/
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Border entry fee study sparks northern opposition
SEATTLE (AP) -- By Michael Hill's estimation, 90 percent of the people pumping gas at his station just south of the U.S.-Canada border in Washington state are Canadians.
Gas north of the 49th parallel, he said, is about $1.30 per gallon more expensive than in the United States. But that's not the only product that Canadians seek in visits to Washington state: Beer, wine and milk are significantly cheaper (beer and wine alone are roughly half the price in the U.S.).
Add a strong Canadian dollar and the result is a key element of the economy in the towns of Whatcom County. For example, the town of Blaine, population just shy of 5,000, generates over $225,000 from a penny per gallon gas tax, which is about 30 percent of its street maintenance budget.
That's why Hill and others are troubled by the notion of charging a fee to enter the U.S. by land. Last month, in its 2014 fiscal year budget proposal, the Department of Homeland Security requested permission to study a fee at the nation's land border crossings.
"It's a deterrent," said Hill, whose station is fully stocked with wine and has a reader board that says "Thank you Canadians."
"They should be doing anything they can to get them down here to buy more," he added.
That lone request sparked wide opposition among members of Congress from northern states, who vowed to stop it. A fee, they say, would hurt communities on the border that rely on people, goods and money moving between the U.S. and Canada.
"The imposition of such a toll would act as a barrier to the greater economic integration that we seek, and is the absolute last thing we should be doing to grow our economy," stated a letter sent to Homeland Security Secretary Janet Napolitano earlier this month signed by 18 Republican and Democratic House lawmakers.
Democrat U.S. Sen. Patrick Leahy of Vermont is sponsoring an amendment to the immigration reform bill that bars Homeland Security from conducting the study. The senator has also promised to stop any funding for the study. In the House, Democrat Rep. Suzan DelBene of Washington state introduced a bill to stop the creation of a fee.
This week an amendment by Democrat Rep. Bill Owens of New York to stop the study was introduced to the House to the Department of Homeland Security Appropriations Bill.
Lawmakers and people from the southern border, though, did not show such strong opposition, highlighting a north-south divide on how to pay for border infrastructure.
Democrat Congressman Ruben E. Hinojosa, who represents a district in Texas that includes McAllen and its nearby border region, said fees would be good if the revenue stream is used to improve infrastructure.
"I would support crossing fees only if the funds garnered would be used to upgrade our facilities, provide better equipment for our agents, or used for the hiring of more agents at our border crossings," Hinojosa said.
Currently it costs nothing to enter the country by land. Air and sea crossings already have a fee of under $2, which are included in ticket prices.
The proposal would mean creating a pilot program that tests all the steps needed to create a fee collection ? short of actually collecting money. The proposed fee would offset costs of providing border screening and infrastructure. Customs and Border Protection did not specify the cost of the study.
The quick response from northern states lawmakers bolsters the thought that the study won't happen this fiscal year, said Ken Oplinger, president of the Bellingham/Whatcom County Chamber of Commerce in Washington state.
But he thinks that due to the expensive border security measures that have been implemented since Sept. 11, the idea could make a comeback in the future unless other sources of funding not reliant on a border fee appear.
One of busiest northern border crossings ? the Peace Arch ? is located in Whatcom County. It connects Washington state with British Columbia. In places, the border is just farmland, with no wall or fence and grazing cows. About 12,000 people cross the border there every day, according to CBP figures.
Oplinger has two main concerns. The lesser is people who will refuse to pay the toll and thus stop visiting Whatcom County all together. His greater worry, however, would be any increase to the wait time at the border. He said border traffic has just fully rebounded to pre-Sept. 11 volumes, adding that on summer weekends the wait to enter the U.S. can be as high as two hours. He fears that adding some sort of mechanism to collect the toll would mean more waiting time.
Border fees, albeit local ones, already exist on the southern border. In Texas, local municipalities charge fees to use bridges that connect Mexico and the U.S.
For Kenn Morris, president of marketing research firm Crossborder Group Inc. in San Diego, the future of the border is in public-private partnerships, unless the government acts to improve ports of entry. For example, a private company operates and builds a port of entry, booths and roads, and charges a fee to recoup investments.
"I think that it's inevitable that more border regions use those tools and those who don't want to use it that's they're choice, but they shouldn't take the ability for other regions to at least look at that option," he said. "For those regions that want the ability to charge a fee, we need good analyses to create good policy."
Citing a 2009 University of Texas study, Morris said tolls at the border don't affect traffic flow negatively, but provide a source of revenue to build more border infrastructure.
At the nation's busiest border entry at San Ysidro in California, 50,000 vehicles and 25,000 pedestrians go north from Mexico every day. For the past few years, Congress has sent chunks of money to improve the infrastructure. In his last budget, President Barack Obama asked for $226 million to continue the improvements.
In the meantime, people face hours of waiting every day.
"People are tired of waiting," Morris said.
____
Manuel Valdes can be reached at http://twitter.com/ByManuelValdes
Source: http://news.yahoo.com/border-entry-fee-study-sparks-142217330.html
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Best Presidents of Mexico
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Olloclip brings distortion-correcting camera app to its three-in-one iPhone lens
As our debut Insert Coin project, the Olloclip will always be near and dear to our hearts, but the handy three-in-one iPhone lens is not without its niggles -- like significant distortion produced by the the wide-angle and fish-eye attachments, for one. Luckily, Olloclip now has a remedy for that in the form of an iPhone camera app that'll correct or enhance such aberrations, depending on which way you want to take your artistry. You'll also get video and macro modes, spot focus and exposure adjustments and a photo library -- all the better to stay footloose and DSLR-free on the road. You can grab it for free at the source.
Filed under: Cellphones, Software
Via: Cult of Mac
Source: Olloclip
Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/mvE4P1ppUx0/
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White House says it was aware of McCain's Syria trip
ON BOARD AIR FORCE ONE (Reuters) - The White House was aware in advance of Republican Senator John McCain's trip to Syria and looks forward to speaking to him upon his return, President Barack Obama's spokesman Jay Carney told reporters on Tuesday.
(Reporting by Steve Holland; Writing by Jeff Mason; Editing by Mohammad Zargham)
Source: http://news.yahoo.com/white-house-aware-mccains-trip-syria-advance-151105064.html
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